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Contents and Authors

Preface

Prefactory Articles

Without a License, or Accidents Waiting to Happen, E. Peter Geiduschek

A Journey in the World of DNA Rings and Beyond, James C. Wang

Biochemistry and Disease Theme

The Biochemistry of Disease: Desperately Seeking Syzygy, John W. Kozarich

Biosynthesis of Phosphonic and Phosphinic Acid Natural Products, William W. Metcalf, Wilfred A. van der Donk

New Antivirals and Drug Resistance, Peter M. Colman

Multidrug Resistance in Bacteria, Hiroshi Nikaido

Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies, Bibek Gooptu, David A. Lomas

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions, Byron Caughey, Gerald S. Baron, Bruce Chesebro, Martin Jeffrey

Ubiquitin-Mediated Protein Regulation Theme

RING Domain E3 Ubiquitin Ligases, Raymond J. Deshaies, Claudio A.P. Joazeiro

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes, Francisca E. Reyes-Turcu, Karen H. Ventii, Keith D. Wilkinson

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome, Daniel Finley

Degradation of Activated Protein Kinases by Ubiquitination, Zhimin Lu, Tony Hunter

The Role of Ubiquitin in NF-κB Regulatory Pathways, Brian Skaug, Xiaomo Jiang, Zhijian J. Chen

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency, Evan T. Powers, Richard I. Morimoto, Andrew Dillin, Jeffery W. Kelly, William E. Balch

Gene Expression Theme

RNA Polymerase Active Center: The Molecular Engine of Transcription, Evgeny Nudler

Genome-Wide Views of Chromatin Structure, Oliver J. Rando, Howard Y. Chang

The Biology of Chromatin Remodeling Complexes, Cedric R. Clapier, Bradley R. Cairns

The Structural and Functional Diversity of Metabolite-Binding Riboswitches, Adam Roth, Ronald R. Breaker

Lipid and Membrane Biogenesis Theme

Genetic and Biochemical Analysis of Non-Vesicular Lipid Traffic, Dennis R. Voelker

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain, David W. Russell, Rebekkah W. Halford, Denise M.O. Ramirez, Rahul Shah, Tiina Kotti

Lipid-Dependent Membrane Protein Topogenesis, William Dowhan, Mikhail Bogdanov

Single-Molecule Studies of the Neuronal SNARE Fusion Machinery, Axel T. Brunger, Keith Weninger, Mark Bowen, Steven Chu

Mechanisms of Endocytosis, Gary J. Doherty, Harvey T. McMahon

Recent Advances in Biochemistry

Motors, Switches, and Contacts in the Replisome, Samir M. Hamdan, Charles C. Richardson

Large-Scale Structural Biology of the Human Proteome, Aled Edwards

Collagen Structure and Stability, Matthew D. Shoulders, Ronald T. Raines

The Structural and Biochemical Foundations of Thiamin Biosynthesis, Christopher T. Jurgenson, Tadhg P. Begley, Steven E. Ealick

Proton-Coupled Electron Transfer in Biology: Results from Synergistic Studies in Natural and Model Systems, Steven Y. Reece, Daniel G. Nocera

Mechanism of Mo-Dependent Nitrogenase , Lance C. Seefeldt, Brian M. Hoffman, Dennis R. Dean

Inorganic Polyphosphate: Essential for Growth and Survival, Narayana N. Rao, María R. Gómez-García, Arthur Kornberg

Essentials for ATP Synthesis by F₁F₀ ATP Synthases, Christoph von Ballmoos, Alexander Wiedenmann, Peter Dimroth

The Chemical Biology of Protein Phosphorylation, Mary Katherine Tarrant, Philip A. Cole

Sphingosine 1-Phosphate Receptor Signaling, Hugh Rosen, Pedro J. Gonzalez-Cabrera, M. Germana Sanna, Steven Brown

The Advent of Near-Atomic Resolution in Single-Particle Electron Microscopy, Yifan Cheng, Thomas Walz

Super-Resolution Fluorescence Microscopy, Bo Huang, Mark Bates, Xiaowei Zhuang

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ISSN: 0066-4154
ISBN: 978-0-8243-0878-0

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